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Joerg H. Schrittwieser, Verena Resch, Johann H. Sattler, Wolf-Dieter Lienhart, Katharina Durchschein, Dr. Andreas Winkler, Prof. Dr. Karl Gruber, Prof. Dr. Peter Macheroux and Prof. Dr. Wolfgang Kroutil Biocatalytic Enantioselective Oxidative C[BOND]C Coupling by Aerobic C[BOND]H Activation Angewandte Chemie International Edition 50

Article first published online: 18 JAN 2011 | DOI: 10.1002/anie.201006268

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Bridging the gap: The berberine bridge enzyme (BBE) was employed for the first preparative oxidative biocatalytic C[BOND]C coupling that leads to a new intramolecular bond. This unique transformation requires O2 as sole stoichiometric oxidant and gives access to novel optically pure (S)-berbine 2 and (R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 1 alkaloid derivatives by kinetic resolution.

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