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Jie Luo, Haifei Wang, Xiao Han, Prof. Dr. Li-Wen Xu, Jacek Kwiatkowski, Prof. Dr. Kuo-Wei Huang and Prof. Dr. Yixin Lu The Direct Asymmetric Vinylogous Aldol Reaction of Furanones with α-Ketoesters: Access to Chiral γ-Butenolides and Glycerol Derivatives Angewandte Chemie International Edition 50

Article first published online: 11 JAN 2011 | DOI: 10.1002/anie.201006316

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Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. The reported method led to the synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile synthesis of chiral glycerol derivatives containing a tertiary hydroxy group has also been demonstrated.

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