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Dr. Elizabeth J. Grayson, Dr. Gonçalo J. L. Bernardes, Justin M. Chalker, Dr. Omar Boutureira, Dr. Julia R. Koeppe and Prof. Benjamin G. Davis A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates Angewandte Chemie International Edition 50

Version of Record online: 31 MAR 2011 | DOI: 10.1002/anie.201006327

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A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).

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