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Dr. Adam Sniady, Dr. Matthew W. Bedore and Prof. Dr. Timothy F. Jamison One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation Angewandte Chemie International Edition 50

Article first published online: 26 JAN 2011 | DOI: 10.1002/anie.201006440

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Nucleosides in flow: A general, scalable method of Brønsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Brønsted acids, particularly pyridinium triflates, can be used. A one-flow multistep synthesis of unprotected nucleosides is also reported (see scheme).

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