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Dr. Nicka Chinkov, Dr. Aleksander Warm and Prof. Dr. Erick M. Carreira Asymmetric Autocatalysis Enables an Improved Synthesis of Efavirenz Angewandte Chemie International Edition 50

Version of Record online: 1 MAR 2011 | DOI: 10.1002/anie.201006689

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Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

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