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Prof. Xiaojun Peng, Tong Wu, Jiangli Fan, Prof. Jingyun Wang, Si Zhang, Fengling Song and Shiguo Sun An Effective Minor Groove Binder as a Red Fluorescent Marker for Live-Cell DNA Imaging and Quantification Angewandte Chemie International Edition 50

Version of Record online: 6 APR 2011 | DOI: 10.1002/anie.201007386

Thumbnail image of graphical abstract

Seeing red: DEAB-TO-3 shows a large fluorescence enhancement upon binding to native DNA and a distinct selectivity for double-stranded DNA over total RNA. As a red fluorescent live-cell-permeant DNA minor groove binder, DEAB-TO-3 is promising for highly sensitive DNA detection in vitro and nucleus-specific imaging and DNA quantification in vivo (see picture).

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