Hendrik Eberhard, Franziska Diezmann and Prof. Dr. Oliver Seitz DNA as a Molecular Ruler: Interrogation of a Tandem SH2 Domain with Self-Assembled, Bivalent DNA–Peptide Complexes Angewandte Chemie International Edition 50
Two peptides on display: The self-assembly of DNA complexes enables the bivalent presentation of phosphopeptides. Flexibility and distance in the ligand arrangement can be adjusted through the choice of appropriate DNA templates. Spatial screening of the tandem SH2 domain of Syk kinase with these probes (see picture) indicated the accessible arrangements of the two homologous binding pockets and the flexibility of the connecting protein linker.
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