Dr. Henning Jacob Jessen, Andreas Schumacher, Travis Shaw, Prof. Dr. Andreas Pfaltz and Prof. Dr. Karl Gademann A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity Angewandte Chemie International Edition 50
Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.
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