E-mail

E-mail a Wiley Online Library Link

Dr. Henning Jacob Jessen, Andreas Schumacher, Travis Shaw, Prof. Dr. Andreas Pfaltz and Prof. Dr. Karl Gademann A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity Angewandte Chemie International Edition 50

Version of Record online: 29 MAR 2011 | DOI: 10.1002/anie.201007671

Thumbnail image of graphical abstract

Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH