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Prof. Dr. Joachim Stöckigt, Dr. Andrey P. Antonchick, Fangrui Wu and Prof. Dr. Herbert Waldmann The Pictet–Spengler Reaction in Nature and in Organic Chemistry Angewandte Chemie International Edition 50

Version of Record online: 9 AUG 2011 | DOI: 10.1002/anie.201008071

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100 years ago Pictet and Spengler discovered the most important method for the synthesis of alkaloid scaffolds—the condensation of aryl ethylamines and aldehydes. Today, efficient enzymatic and non-enzymatic methods are both available for the Pictet–Spengler reaction.

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