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Xin Gao, Dr. Yong Jian Zhang and Prof. Michael J. Krische Iridium-Catalyzed anti-Diastereo- and Enantioselective Carbonyl (α-Trifluoromethyl)allylation from the Alcohol or Aldehyde Oxidation Level Angewandte Chemie International Edition 50

Version of Record online: 6 APR 2011 | DOI: 10.1002/anie.201008296

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A flourish of fluorine: Exposure of α-trifluoromethyl allyl benzoate to alcohols in the presence of an ortho-cyclometalated iridium catalyst results in the generation of aldehyde–allyliridium intermediates to form enantiomerically enriched products of anti-(α-trifluoromethyl)allylation. An identical set of products is obtained from aldehydes under related transfer hydrogenation conditions employing isopropyl alcohol as terminal reductant.

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