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Dr. Philippe Marlière, Julien Patrouix, Dr. Volker Döring, Prof. Dr. Piet Herdewijn, Sabine Tricot, Dr. Stéphane Cruveiller, Dr. Madeleine Bouzon and Prof. Dr. Rupert Mutzel Chemical Evolution of a Bacterium’s Genome Angewandte Chemie International Edition 50

Article first published online: 27 JUN 2011 | DOI: 10.1002/anie.201100535

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Automated selection was used to evolve an Escherichia coli strain unable to synthesize thymine nucleotides into a chemically modified organism whose DNA genome is composed of adenine, cytosine, guanine, and an artificial base, the thymine analogue 5-chlorouracil. Evolving cells were initially observed as irregular filaments and progressively recovered the appearance of short rods typical of wild-type E. coli (see picture).

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