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Dr. Carlos González-Rodríguez, Rebekah J. Pawley, Dr. Adrian B. Chaplin, Dr. Amber L. Thompson, Prof. Andrew S. Weller and Dr. Michael C. Willis Rhodium-Catalyzed Branched-Selective Alkyne Hydroacylation: A Ligand-Controlled Regioselectivity Switch Angewandte Chemie International Edition 50

Version of Record online: 19 APR 2011 | DOI: 10.1002/anie.201100956

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It's all in the ligand: By choice of the appropriate diphosphine ligand a previously linear-selective alkyne hydroacylation process can be “switched” to be highly branched-selective (see scheme, l=linear, b=branched). Structural data for the ortho-iPr-dppe–rhodium catalyst suggest restricted rotation of the phosphine aryl units may be responsible for the observed selectivity.

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