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Dr. Haibo Wang, Dr. Qing Zhang, Prof. Dr. Xia Chu, Dr. Tingting Chen, Dr. Jia Ge and Prof. Ruqin Yu Graphene Oxide–Peptide Conjugate as an Intracellular Protease Sensor for Caspase-3 Activation Imaging in Live Cells Angewandte Chemie International Edition 50

Version of Record online: 16 JUN 2011 | DOI: 10.1002/anie.201101351

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All systems GO! An intracellular protease sensor is based on the covalent conjugate of graphene oxide and peptide substrates with fluorophore labels. The conjugate can be delivered into live cells and provides specific, high-contrast imaging of caspase-3 activation (see picture; orange=cell penetration peptide, blue/black=caspase-3 peptide probe).

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