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Dr. Sangkyu Lee, Dr. Kyoung Hu Lee, Dr. Jae-Seok Ha, Dr. Seung-Goo Lee and Dr. Tae K. Kim Small-Molecule-Based Nanoassemblies as Inducible Nanoprobes for Monitoring Dynamic Molecular Interactions Inside Live Cells Angewandte Chemie International Edition 50

Version of Record online: 27 JUL 2011 | DOI: 10.1002/anie.201101467

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Seeing into cells: Genetically engineered, labeled ferritin is used to form biological nanoparticles displaying bait (B) and prey (P) molecules inside cells (see picture). Specific bait–prey interactions induce the interconnected assembly of nanoparticles into nanoclusters on a timescale of seconds. This phenotypic readout with a small molecule as an inducible switch was used to directly visualize dynamic molecular interactions within living cells.

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