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Dr. Kuo-Ching Chu, Dr. Chien-Tai Ren, Dr. Chun-Ping Lu, Che-Hsiung Hsu, Dr. Tsung-Hsien Sun, Dr. Jeng-Liang Han, Dr. Bikash Pal, Tsung-An Chao, Yung-Feng Lin, Prof. Shih-Hsiung Wu, Prof. Chi-Huey Wong and Prof. Chung-Yi Wu Efficient and Stereoselective Synthesis of α(2[RIGHTWARDS ARROW]9) Oligosialic Acids: From Monomers to Dodecamers Angewandte Chemie International Edition 50

Article first published online: 29 AUG 2011 | DOI: 10.1002/anie.201101794

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The chain gang: The α(2[RIGHTWARDS ARROW]9) dodecasialic acid has been stereoselectively synthesized in 12 steps by using a convergent block synthesis (see scheme). The use of chloroacetyl protecting groups and a phosphate group as a leaving group led to the improvement of the α selectivity of the glycosylation reactions, thus allowing synthesis of oligomers.

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