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Antonina S. Lygina, Karsten Meyenberg, Prof. Dr. Reinhard Jahn and Prof. Dr. Ulf Diederichsen Transmembrane Domain Peptide/Peptide Nucleic Acid Hybrid as a Model of a SNARE Protein in Vesicle Fusion Angewandte Chemie International Edition 50

Article first published online: 22 JUL 2011 | DOI: 10.1002/anie.201101951

Thumbnail image of graphical abstract

Artificial models of the natural SNARE proteins containing the native linker regions (light blue/gray) and the transmembrane domains (TMDs) of synatobrevin (Syb, violet) and syntaxis-1A (Sx, orange) along with a peptide nucleic acid (PNA) recognition motif can align with either an antiparallel (see picture) or parallel orientation of the interacting strands. These hybrids induce the hemifusion and partial bilayer fusion of phospholipid vesicles.

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