Jie Geng, Meng Li, Prof. Jinsong Ren, Prof. Enbo Wang and Prof. Xiaogang Qu Inside Cover: Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease (Angew. Chem. Int. Ed. 18/2011) Angewandte Chemie International Edition 50
Four types of polyoxometalates(POMs) have been found to be efficient inhibitors of amyloid formation by amyloid β peptides (Aβ) associated with Alzheimer's disease. X. Qu and co-workers show in their Communication on page 4184 ff. that the inhibition selectivity of the POMs is due to size-specific electrostatic interactions between the POMs and Aβ, with the POMs binding to the positively charged His13–Lys16 cluster region of Aβ.
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