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Dr. Thomas A. Knappe, Dr. Florian Manzenrieder, Dr. Carlos Mas-Moruno, Dr. Uwe Linne, Dr. Florenz Sasse, Prof. Dr. Horst Kessler, Dr. Xiulan Xie and Prof. Dr. Mohamed A. Marahiel Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist Angewandte Chemie International Edition 50

Version of Record online: 2 AUG 2011 | DOI: 10.1002/anie.201102190

Thumbnail image of graphical abstract

Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the integrin binding motif RGD onto the lasso structure of microcin J25 converts the knotted peptide into a nanomolar integrin antagonist (see picture). Engineered lasso peptides can therefore be used for pharmacophore presentation.

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