Clarissa S. Sit, Marco J. van Belkum, Ryan T. McKay, Prof. Randy W. Worobo and Prof. John C. Vederas The 3D Solution Structure of Thurincin H, a Bacteriocin with Four Sulfur to α-Carbon Crosslinks Angewandte Chemie International Edition 50
Problem solved: Thurincin H is an antimicrobial peptide with suspected post-translational modifications. MS/MS sequencing identified the residues that were modified, and NMR spectroscopic studies in solution led to the 3D structure of thurincin H, which features four SCα thioether crosslinks (yellow in schematic representation). This structure may be representative of several other bacteriocins with identical masses.
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