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Magali Lorenzi, Carine Puppo, Dr. Régine Lebrun, Sabrina Lignon, Dr. Valérie Roubaud, Dr. Marlène Martinho, Dr. Elisabetta Mileo, Prof. Paul Tordo, Prof. Sylvain R. A. Marque, Dr. Brigitte Gontero, Prof. Bruno Guigliarelli and Dr. Valérie Belle Tyrosine-Targeted Spin Labeling and EPR Spectroscopy: An Alternative Strategy for Studying Structural Transitions in Proteins Angewandte Chemie International Edition 50

Article first published online: 24 AUG 2011 | DOI: 10.1002/anie.201102539

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Keeping tabs on tyrosine: A three-component Mannich-type reaction extends the scope of site-directed spin labeling by selectively labeling the unique tyrosine residue of CP12 protein (see picture), as was confirmed by mass spectrometry. EPR spectroscopy of the labeled protein showed a very high mobility of the probe, which remained very mobile after complex formation with GAPDH.

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