Dr. Elena Aznar, Dr. Laura Mondragón, Dr. José V. Ros-Lis, Dr. Félix Sancenón, Dr. M. Dolores Marcos, Prof. Ramón Martínez-Máñez, Dr. Juan Soto, Prof. Enrique Pérez-Payá and Prof. Pedro Amorós Finely Tuned Temperature-Controlled Cargo Release Using Paraffin-Capped Mesoporous Silica Nanoparticles Angewandte Chemie International Edition 50
Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle (see picture). Upon melting of the paraffin, the guest molecule is released, as demonstrated in cells for the guest doxorubicin. The release temperature can be tuned by choosing an appropriate paraffin.
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