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Vanessa K. Lacey, Angela R. Parrish, Shuliang Han, Dr. Zhouxin Shen, Prof. Steven P. Briggs, Prof. Yuguo Ma and Prof. Lei Wang A Fluorescent Reporter of the Phosphorylation Status of the Substrate Protein STAT3 Angewandte Chemie International Edition 50

Article first published online: 29 JUL 2011 | DOI: 10.1002/anie.201102923

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Roving reporter: A reversible biosensor reports the phosphorylation status of full-length substrate protein STAT3 by genetically incorporating 7-hydroxycoumarin into its phosphotyrosine binding pocket (see picture). A large fluorescence increase with characteristic emission and excitation properties results as a response to phosphorylation of STAT3 in vitro and endogenously in nuclear extracts.

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