E-mail a Wiley Online Library Link

Kelvin S. L. Chan, Masayuki Wasa, Dr. Xisheng Wang and Prof. Dr. Jin-Quan Yu Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach Angewandte Chemie International Edition 50

Version of Record online: 11 JUL 2011 | DOI: 10.1002/anie.201102985

Thumbnail image of graphical abstract

Finally, a choice! A highly selective palladium(II)-catalyzed ortho-monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl). Simple modification of this protocol allows for a choice between mono- and difluorination. The mono- and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field