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Kelvin S. L. Chan, Masayuki Wasa, Dr. Xisheng Wang and Prof. Dr. Jin-Quan Yu Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach Angewandte Chemie International Edition 50

Version of Record online: 11 JUL 2011 | DOI: 10.1002/anie.201102985

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Finally, a choice! A highly selective palladium(II)-catalyzed ortho-monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl). Simple modification of this protocol allows for a choice between mono- and difluorination. The mono- and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries.

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