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Cornelis Smit, Julia Blümer, Martijn F. Eerland, Michael F. Albers, Matthias P. Müller, Prof. Dr. Roger S. Goody, Dr. Aymelt Itzen and Dr. Christian Hedberg Efficient Synthesis and Applications of Peptides containing Adenylylated Tyrosine Residues Angewandte Chemie International Edition 50

Version of Record online: 25 AUG 2011 | DOI: 10.1002/anie.201103203

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The enzyme DrrA of the human pathogen Legionella pneumophila adenylylates specifically a tyrosine of the GTPase Rab1. An efficient synthesis route using Fmoc solid phase peptide synthesis led to Tyr-adenylylated peptides and allowed the generation of mono-selective polyclonal antibodies against this post-translational modification.

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