Dipl.-Chem. Stefan Benson, Dr. Marie-Pierre Collin, Dipl.-Chem. Alexander Arlt, Barbara Gabor, Dr. Richard Goddard and Prof. Alois Fürstner Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route Angewandte Chemie International Edition 50
Outlandish: The spiroketal embedded in spirastrellolide F methyl ester is a daring site for ring closure, yet it has allowed the power of catalytic alkyne scission and activation to be showcased (see scheme). An improved strategy for the introduction of the labile side chain was also developed.
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