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Dr. Ghyslain Budin, Dr. Katherine S. Yang, Dr. Thomas Reiner and Prof. Ralph Weissleder Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification Angewandte Chemie International Edition 50

Article first published online: 24 AUG 2011 | DOI: 10.1002/anie.201103273

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Click inside: A nuclear protein target, polo-like kinase 1 (PLK1) was imaged using a biocompatible bioorthogonal ligation between a specific drug and a fluorescent dye in live cells (see picture). Colocalization of the dye and the protein target was confirmed by antibody staining and by expressing a GFP construct of PLK1. The two-step PLK1 imaging procedure was used to quantify PLK1 expression levels in cancer cell lines of various tissue origins.

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