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Dr. Miki Imanishi, Dr. Atsushi Nakamura, Dr. Masao Doi, Prof. Shiroh Futaki and Prof. Hitoshi Okamura Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator Angewandte Chemie International Edition 50

Version of Record online: 8 SEP 2011 | DOI: 10.1002/anie.201103307

Thumbnail image of graphical abstract

I got rhythm: The circadian clock is driven by transcription–translation feedback loops. The circadian time can be altered by creating an artificial zinc finger protein specifically binding to the glucocorticoid responsive element (GRE) on the Period1 promoter (see picture; DD=destabilizing domain, AD=activation domain). This artificial protein directly controls the clock machinery.

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