Dr. Chih-Ming Chou, Indranil Chatterjee and Prof. Dr. Armido Studer Stereospecific Palladium-Catalyzed Decarboxylative C(sp3)C(sp2) Coupling of 2,5-Cyclohexadiene-1-carboxylic Acid Derivatives with Aryl Iodides Angewandte Chemie International Edition 50
Walk on the same side! The title reaction occurs by means of highly stereospecific 1,3-metal migration. The starting carboxylic acids are readily prepared by Birch reduction, and the developed protocol provides an efficient route to enantiomerically pure 5-arylated-1,3-cyclohexadiene derivatives (see scheme).
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