Kuangwen Hsieh, Dr. Ryan J. White, Dr. Brian S. Ferguson, Prof. Kevin W. Plaxco, Dr. Yi Xiao and Prof. H. Tom Soh Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches Angewandte Chemie International Edition 50
Getting a response: A surface-bound and redox-modified (methylene blue) DNA probe architecture is at the heart of a sensor for detecting single-nucleotide mismatched targets with a “polarity-switching” response. It outputs a decreased Faradaic current when hybridized to a perfectly matched (PM) target, and an increased Faradaic current when hybridized to a single-base mismatched (SM) target (see scheme).
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