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Dr. Soumava Santra and Prof. Dr. Peter R. Andreana A Bioinspired Ugi/Michael/Aza-Michael Cascade Reaction in Aqueous Media: Natural-Product-like Molecular Diversity Angewandte Chemie International Edition 50

Article first published online: 25 AUG 2011 | DOI: 10.1002/anie.201103567

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Whole in one! A one-pot microwave-assisted reaction sequence that consists of an Ugi/Michael/aza-Michael transformation gives access to quaternary spirocenters leading to Amaryllidaceae and Erythrina alkaloid like compounds (see scheme). The process produces four stereogenic centers and six contiguous bonds, and provides products with good to excellent yields and appreciable diastereoselectivity.

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