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Sergey V. Tsukanov and Prof. Dr. Daniel L. Comins Concise Total Synthesis of the Frog Alkaloid (−)-205 B Angewandte Chemie International Edition 50

Article first published online: 26 JUL 2011 | DOI: 10.1002/anie.201103596

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Highly stereocontrolled: The total synthesis of frog alkaloid (−)-205B features a chiral N-acylpyridinium salt reaction and an unprecedented trifluoroacetic anhydride mediated addition of an allylstannane to a vinylogous amide. The core was assembled using a Tsuji–Trost allylic amination reaction and a ring-closing metathesis. TIPS=triisopropylsilyl.

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