Dr. Jian Dai, Shudong Lin, Dr. Du Cheng, Seyin Zou and Prof. Xintao Shuai Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release Angewandte Chemie International Edition 50
On the double: A highly packed interlayer-crosslinked micelle (HP-ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP-ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual-sensitive HP-ICM in cancer treatment.
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