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Dr. Andrew T. Parsons and Prof. Dr. Stephen L. Buchwald Copper-Catalyzed Trifluoromethylation of Unactivated Olefins Angewandte Chemie International Edition 50

Article first published online: 25 AUG 2011 | DOI: 10.1002/anie.201104053

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Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.

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