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Dr. Xiaoxing Wu, Dr. Brett P. Fors and Prof. Dr. Stephen L. Buchwald A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C[BOND]O Bond Formation with Secondary and Primary Alcohols Angewandte Chemie International Edition 50

Version of Record online: 12 SEP 2011 | DOI: 10.1002/anie.201104361

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Forging a bond: An efficient, general palladium catalyst for C[BOND]O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.

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