Lian Wang, Wei Meng, Chuan-Le Zhu, Dr. Yan Zheng, Dr. Jing Nie and Prof. Jun-An Ma The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination Angewandte Chemie International Edition 50
Long arm of the law: The long-armed phosphoramidite 1 was used as a catalyst for the title reaction of acyclic alkylidene β-ketoesters with dialkylzinc and fluorinating reagents. The products, containing adjacent carbon- and fluorine-substituted stereocenters, are obtained in high yield as well as diastereo- and enantioselectivity. NSFI=N-fluorobenzenesulfonimide.
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