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Dr. Abhigyan Som, Anika Reuter and Prof. Gregory N. Tew Protein Transduction Domain Mimics: The Role of Aromatic Functionality Angewandte Chemie International Edition 51

Version of Record online: 13 DEC 2011 | DOI: 10.1002/anie.201104624

Thumbnail image of graphical abstract

For better or worse: Protein transduction domain mimics built from synthetic polymers demonstrate that aromatic side chains provide better transduction than aliphatic groups at the same relative hydrophobicity. Similarly, a less hydrophobic aromatic side chain is more active than the corresponding aliphatic one containing the same number of carbon atoms (see picture).

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