Prof. José Barluenga, Ana Álvarez-Fernández, Dr. Ángel L. Suárez-Sobrino and Prof. Miguel Tomás Regio- and Stereoselective Synthesis of Cyclopentenones: Intermolecular Pseudo-Pauson–Khand Cyclization Angewandte Chemie International Edition 51
Doing the two step: A very simple two-step access to polysubstituted cyclopentenones from terminal alkynes, [M(CO)6], and bromoalkenes is described. This protocol is an alternative to the intermolecular Pauson–Khand reaction, and can be used with a variety of bromoalkenes. Moreover, the final quenching allows the installation of reactive electrophiles (E). The enantiopure product cyclopentenones can be synthesized with an all-carbon-substituted quaternary stereocenter.
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