Tim Geppert, Stefanie Bauer, Dr. Jan A. Hiss, Elea Conrad, Michael Reutlinger, Dr. Petra Schneider, Dr. Martin Weisel, Bernhard Pfeiffer, Prof. Dr. Karl-Heinz Altmann, Priv.-Doz. Dr. Zoe Waibler and Prof. Dr. Gisbert Schneider Immunosuppressive Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein–Protein Interactions Angewandte Chemie International Edition 51
Version of Record online: 16 NOV 2011 | DOI: 10.1002/anie.201105901
Interfering with interferon: A low-molecular-weight inhibitor has been discovered that blocks the interaction between interferon-α (IFN-α) and its receptor (see picture for a model of the interfaces). The resulting lead compound significantly reduces IFN-α production in vitro. NMR and SPR experiments confirm the direct interaction of the inhibitor with IFN-α.
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