E-mail

E-mail a Wiley Online Library Link

Tim Geppert, Stefanie Bauer, Dr. Jan A. Hiss, Elea Conrad, Michael Reutlinger, Dr. Petra Schneider, Dr. Martin Weisel, Bernhard Pfeiffer, Prof. Dr. Karl-Heinz Altmann, Priv.-Doz. Dr. Zoe Waibler and Prof. Dr. Gisbert Schneider Immunosuppressive Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein–Protein Interactions Angewandte Chemie International Edition 51

Version of Record online: 16 NOV 2011 | DOI: 10.1002/anie.201105901

Thumbnail image of graphical abstract

Interfering with interferon: A low-molecular-weight inhibitor has been discovered that blocks the interaction between interferon-α (IFN-α) and its receptor (see picture for a model of the interfaces). The resulting lead compound significantly reduces IFN-α production in vitro. NMR and SPR experiments confirm the direct interaction of the inhibitor with IFN-α.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH