Dr. Satoshi Yamaguchi, Shinya Yamahira, Kyoko Kikuchi, Kimio Sumaru, Toshiyuki Kanamori and Prof. Teruyuki Nagamune Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid Angewandte Chemie International Edition 51
Cells in the spotlight: A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG-coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high-contrast cell pattern. Only the targeted cells on the cell pattern were selectively detached without cell damage on a microfluidic device (see picture).
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