E-mail a Wiley Online Library Link

Dr. Ivana Gazić Smilović, Dr. Eva Casas-Arcé, Dr. Stephen J. Roseblade, Dr. Ulrike Nettekoven, Dr. Antonio Zanotti-Gerosa, Dr. Miroslav Kovačevič and Dr. Zdenko Časar Iridium-Catalyzed Chemoselective and Enantioselective Hydrogenation of (1-Chloro-1-Alkenyl) Boronic Esters Angewandte Chemie International Edition 51

Article first published online: 16 DEC 2011 | DOI: 10.1002/anie.201106262

Thumbnail image of graphical abstract

Persistent chlorine: Hydrogenation of borolane-substituted vinylic chlorides catalyzed by Ir[BOND]P N complexes greatly preserved the chlorine substituent on the hydrogenated product, with only 3–19 % of dechlorinated byproducts present after hydrogenation. The α-chloro boronic ester products are ideal precursors for proteasome-inhibitor-type anti-cancer drugs, a fact which demonstrates the utility of this hydrogenation method.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field