Gabriela de Almeida, Ellen M. Sletten, Hitomi Nakamura, Krishnan K. Palaniappan and Prof. Carolyn R. Bertozzi Thiacycloalkynes for Copper-Free Click Chemistry Angewandte Chemie International Edition 51
The heteroatom helps! The introduction of an endocyclic sulfur atom enables fine-tuning of the reactivity and stability of thiacycloalkynes for copper-free click chemistry. The stabilizing effect of the endocyclic sulfur atom allows the use of highly activated seven-membered rings as reagents for bioorthogonal copper-free click chemistry.
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