Dr. Sarra C. Sebai, Dimitra Milioni, Dr. Astrid Walrant, Dr. Isabel D. Alves, Dr. Sandrine Sagan, Dr. Cécile Huin, Dr. Loic Auvray, Dominique Massotte, Prof. Sophie Cribier and Dr. Christophe Tribet Photocontrol of the Translocation of Molecules, Peptides, and Quantum Dots through Cell and Lipid Membranes Doped with Azobenzene Copolymers Angewandte Chemie International Edition 51
Light opens: Photocontrolled transmembrane passage of soluble dyes and delivery of small peptides into mammalian cells has been achieved using azobenzene-modified polymers (AMPs) as permeabilizing agents. Irradiation with UV and visible light triggers polarity switches upon cis–trans isomerization of the azobenzene moieties. Photoresponsive permeability and pore opening promoted by trans-AMPs, but not cis-AMPs, in supported lipid bilayers are observed.
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