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Hailing Li and Prof. Dr. Alexandre Alexakis Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation Angewandte Chemie International Edition 51

Version of Record online: 8 DEC 2011 | DOI: 10.1002/anie.201107129

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A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.

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