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Dr. Yuanpei Li, Dr. Wenwu Xiao, Dr. Kai Xiao, Dr. Lorenzo Berti, Prof. Juntao Luo, Harry P. Tseng, Gabriel Fung and Prof. Kit S. Lam Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols Angewandte Chemie International Edition 51

Version of Record online: 17 JAN 2012 | DOI: 10.1002/anie.201107144

Thumbnail image of graphical abstract

Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.

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