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Dr. Yuze Sun and Prof. Dr. Xudong Fan Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers Angewandte Chemie International Edition 51

Article first published online: 23 DEC 2011 | DOI: 10.1002/anie.201107381

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Laser precision: A highly sensitive technique based on laser emission for differentiating a target DNA strand from strands that contain single base mismatches has been developed. Laser emission is used to amplify the small difference in signals that are generated by the different strands after hybridization with a molecular beacon (MB, see picture) in a conversion that is similar to analog-to-digital.

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