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Dr. François Lévesque and Prof. Dr. Peter H. Seeberger Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin Angewandte Chemie International Edition 51

Article first published online: 16 JAN 2012 | DOI: 10.1002/anie.201107446

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Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

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