Dr. Pavel Nagorny, Dr. Neeraj Sane, Dr. Bernhard Fasching, Dr. Baptiste Aussedat and Prof. Dr. Samuel J. Danishefsky Probing the Frontiers of Glycoprotein Synthesis: The Fully Elaborated β-Subunit of the Human Follicle-Stimulating Hormone Angewandte Chemie International Edition 51
Ambitious undertaking: The β-subunit of the human follicle-stimulating hormone (hFSH) displaying a N-linked consensus sequence oligosaccharide at each of the two wild-type sites was synthesized. The glycoprotein has been designed with acetamidomethyl protected cysteine residues, anticipating folding and association with the α-subunit. This represents the largest realistically glycosylated homogeneous glycoprotein obtained by using strictly chemical methods.
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