E-mail a Wiley Online Library Link

Dr. Pavel Nagorny, Dr. Neeraj Sane, Dr. Bernhard Fasching, Dr. Baptiste Aussedat and Prof. Dr. Samuel J. Danishefsky Probing the Frontiers of Glycoprotein Synthesis: The Fully Elaborated β-Subunit of the Human Follicle-Stimulating Hormone Angewandte Chemie International Edition 51

Version of Record online: 9 DEC 2011 | DOI: 10.1002/anie.201107482

Thumbnail image of graphical abstract

Ambitious undertaking: The β-subunit of the human follicle-stimulating hormone (hFSH) displaying a N-linked consensus sequence oligosaccharide at each of the two wild-type sites was synthesized. The glycoprotein has been designed with acetamidomethyl protected cysteine residues, anticipating folding and association with the α-subunit. This represents the largest realistically glycosylated homogeneous glycoprotein obtained by using strictly chemical methods.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field