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Daniel A. DiRocco, Elizabeth L. Noey, Prof. K. N. Houk and Prof. Tomislav Rovis Catalytic Asymmetric Intermolecular Stetter Reactions of Enolizable Aldehydes with Nitrostyrenes: Computational Study Provides Insight into the Success of the Catalyst Angewandte Chemie International Edition 51

Version of Record online: 26 JAN 2012 | DOI: 10.1002/anie.201107597

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Fluorine helps: A fluorinated triazolium salt precatalyst has been developed that efficiently promotes the asymmetric intermolecular Stetter reaction of enolizable aldehydes and nitrostyrenes (see scheme). Trans fluorination of the catalyst architecture results in unparalleled reactivity and enantioselectivity in the desired transformation. A DFT study provides evidence of an electrostatic interaction as the source of the increased enantio-induction.

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