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Dr. Jonathan T. Reeves, Zhulin Tan, Dr. Zhengxu S. Han, Dr. Guisheng Li, Dr. Yongda Zhang, Yibo Xu, Dr. Diana C. Reeves, Dr. Nina C. Gonnella, Dr. Shengli Ma, Dr. Heewon Lee, Dr. Bruce Z. Lu and Dr. Chris H. Senanayake Direct Titanium-Mediated Conversion of Ketones into Enamides with Ammonia and Acetic Anhydride Angewandte Chemie International Edition 51

Article first published online: 3 JAN 2012 | DOI: 10.1002/anie.201107601

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A one-step conversion of ketones into N-acetyl enamides was developed. The process employs safe and inexpensive reagents, proceeds under mild conditions, and tolerates diverse functional groups. The addition of edte (N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine) prior to workup enables water solubilization of Ti alkoxides and allows a simple extractive workup.

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