Dipl.-Bioinf. Philipp Thiel, Prof. Dr. Markus Kaiser and Dr. Christian Ottmann Small-Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery? Angewandte Chemie International Edition 51
Doing it the other way round: The modulation of protein–protein interactions (PPIs) by small molecules has become increasingly popular over the last few decades. However, “modulation” has mainly been perceived as “inhibition” of protein–protein interactions, omitting the complementary strategy of stabilizing such macromolecular complexes. This Minireview highlights amazing examples and the potential of this constructive side of modulating PPIs.
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